CASC 5 ( cancer sensitibity candidate 5 )
نویسنده
چکیده
D40/CASC5 mRNA expression is dominant in normal human testis and slight expression are observed in other organs, such as placenta. At least two alternative isoforms of cDNA were identified. Northern blotting analysis on testis shows two bands with size of approximately 6 and 8.5 kb which are probably derived from the two isoforms. Analysis on cancer cell lines, such as HeLa, gave single band with 8.5 kb. There is another alternative splicing site at the 5’ side of this gene that generates a short exon with 78 bp in cDNA. There are potential other alternative splicing at cancer cell lines.
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